|
|
S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine
|
2.1.1.160
caffeine synthase
|
–
|
MK
|
| |
BRENDA:
BR48814
KEGG:
R07920
MetaCyc:
RXN-7599
SABIO-RK:
14238
|
|
|
|
S-adenosyl-L-methionine + paraxanthine <=> H+ + Caffeine + S-adenosyl-L-homocysteine
|
2.1.1.159
theobromine synthase
2.1.1.160
caffeine synthase
|
–
–
|
MK
|
| |
BRENDA:
BR48815
KEGG:
R07921
MetaCyc:
RXN-7601
SABIO-RK:
14236
|
|
|
|
Caffeine + ubiquinone + H2O <=> 1,3,7-trimethyluric_acid + ubiquinol
|
1.17.5.2
caffeine dehydrogenase
|
–
|
MK
|
| |
BRENDA:
BR49384
KEGG:
R07980
MetaCyc:
RXN-11523
|
|
|
|
Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
BMK
|
| |
BRENDA:
BR50577
KEGG:
R07956
MetaCyc:
RXN-11513
|
|
|
|
Caffeine + NADH + O2 + H+ <=> Theobromine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
K
|
| |
BRENDA:
BR50577-a
KEGG:
R07955
MetaCyc:
RXN-11513_WOP
|
|
|
|
Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
K
|
| |
BRENDA:
BS411830
KEGG:
R07954
MetaCyc:
RXN-13106_WOP
|
|
|
|
Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
MK
|
| |
BRENDA:
BS417832
KEGG:
R07939
MetaCyc:
RXN-13106
|
|
|
|
Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O
|
1.13.12
1.14.13.128
7-methylxanthine demethylase
|
–
–
|
K
|
| |
BRENDA:
BS417831
KEGG:
R07972
|
|
|
|
Caffeine + NADH + H+ + O2 <=> theophylline + NAD+ + formaldehyde + H2O
|
1.13.12
|
–
|
K
|
| |
KEGG:
R07971
|
|
|
|
Caffeine + O2 + H2O <=> 1,3,7-trimethyluric_acid + H2O2
|
not assigned
|
–
|
M
|
| |
MetaCyc:
RXN-11522
|
|
|
|
Caffeine + demethylated_methyl_donor <=> theophylline + alkane
|
not assigned
|
–
|
M
|
| |
MetaCyc:
RXN-11544
|
|
|
|
Caffeine <=> 1,3,7-trimethyluric_acid
|
not assigned
|
–
|
M
|
| |
MetaCyc:
RXN-11548
|
|
|
|
Caffeine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> paraxanthine + oxidized_[NADPH-hemoprotein_reductase] + formaldehyde + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
| |
MetaCyc:
RXN66-598
|
|
|
|
Caffeine + H+ <=> Caffeine + H+
|
not assigned
|
–
|
|
| |
MetaCyc:
TRANS-RXN-202
|
|
|
|
Caffeine + 2 O2 + 2 NADH + 2 H+ <=> 7-methylxanthine + 2 NAD+ + 2 H2O + 2 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
| |
BRENDA:
BS411828
|
|
|
|
Caffeine + 3 O2 + 3 NADH + 3 H+ <=> xanthine + 3 NAD+ + 3 H2O + 3 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
| |
BRENDA:
BS411829
|
|
|
|
Caffeine + 2,3-dimethoxy-5-methyl-1,4-benzoquinone <=> 1,3,7-trimethyluric_acid + reduced_coenzyme_Q0
|
1.17.5.2
caffeine dehydrogenase
|
–
|
|
| |
BRENDA:
BS411832
|
|
|
|
ATP + H2O + Caffeine <=> ADP + phosphate + Caffeine
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
| |
BRENDA:
BS433448
|
|
